Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50006970
Substrate
n/a
Meas. Tech.
ChEMBL_201280 (CHEMBL805614)
Ki
8.3±n/a nM
Citation
 Glennon, RA; Ismaiel, AM; Smith, JD; Yousif, M; el-Ashmawy, M; Herndon, JL; Fischer, JB; Howie, KJ; Server, AC Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors. J Med Chem 34:1855-9 (1991) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50006970
Synonyms:
CHEMBL293952 | [2-(4-Iodo-phenyl)-1-methyl-ethyl]-(3-phenyl-propyl)-amine
Type:
Small organic molecule
Emp. Form.:
C18H22IN
Mol. Mass.:
379.2785
SMILES:
CC(Cc1ccc(I)cc1)NCCCc1ccccc1
Structure:
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