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Target
Aromatase
Ligand
BDBM50332807
Substrate
n/a
Meas. Tech.
ChEMBL_50722 (CHEMBL666801)
IC50
530±n/a nM
Citation
 Numazawa, M; Mutsumi, A; Hoshi, K; Oshibe, M; Ishikawa, E; Kigawa, H Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitors. J Med Chem 34:2496-504 (1991) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Homo sapiens (Human)
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50332807
Synonyms:
(8R,9S,10R,13S,14S)-10,13-dimethyl-2,3,7,8,9,10,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[alpha]phenanthren-17(6H)-one | CHEMBL1629804
Type:
Small organic molecule
Emp. Form.:
C19H28O
Mol. Mass.:
272.425
SMILES:
C[C@]12CC[C@H]3[C@@H](CCC4=CCCC[C@]34C)[C@@H]1CCC2=O |r,t:8|
Structure:
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