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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50008049
Substrate
n/a
Meas. Tech.
ChEBML_62000
IC50
86±n/a nM
Citation
 Lewin, AH; Gao, YG; Abraham, P; Boja, JW; Kuhar, MJ; Carroll, FI 2 beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor. J Med Chem 35:135-40 (1992) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50008049
Synonyms:
3-Benzoyloxy-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 2-[4-(3-ethoxycarbonyl-propionylamino)-phenyl]-ethyl ester; hydrochloride | CHEMBL541526
Type:
Small organic molecule
Emp. Form.:
C30H36N2O7
Mol. Mass.:
536.616
SMILES:
CCOC(=O)CCC(=O)Nc1ccc(CCOC(=O)C2C3CC[C@H](C[C@@H]2OC(=O)c2ccccc2)N3C)cc1 |TLB:36:35:19.25.24:21.22,THB:26:25:35:21.22,17:19:35:21.22|
Structure:
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