Reaction Details Report a problem with these data
Target
72 kDa type IV collagenase
Ligand
BDBM50001010
Substrate
n/a
Meas. Tech.
ChEBML_49492
IC50
17000±n/a nM
Citation
 Bols, M; Binderup, L; Hansen, J; Rasmussen, P Inhibition of collagenase by aranciamycin and aranciamycin derivatives. J Med Chem 35:2768-71 (1992) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50001010
Synonyms:
4-[4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-3-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-2,5,7-trihydroxy-3-methoxy-2-methyl-3,4-dihydro-2H-naphthacene-1,6,11-trione | CHEMBL92283
Type:
Small organic molecule
Emp. Form.:
C33H42O12Si
Mol. Mass.:
658.7649
SMILES:
COC1C(O[C@H]2[C@H](OC)[C@](C)(O)C(=O)c3cc4C(=O)c5cccc(O)c5C(=O)c4c(O)c23)OC(C)C(O)C1O[Si](C)(C)C(C)(C)C
Structure:
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