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Target
Histamine H1 receptor
Ligand
BDBM50368376
Substrate
n/a
Meas. Tech.
ChEMBL_218827 (CHEMBL823938)
IC50
1200±n/a nM
Citation
 Diurno, MV; Mazzoni, O; Piscopo, E; Calignano, A; Giordano, F; Bolognese, A Synthesis and antihistaminic activity of some thiazolidin-4-ones. J Med Chem 35:2910-2 (1992) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50368376
Synonyms:
CHEMBL1202938
Type:
Small organic molecule
Emp. Form.:
C15H22N2OS
Mol. Mass.:
278.413
SMILES:
CN(C)CCCN1C(SCC1=O)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: