Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50003160
Substrate
n/a
Meas. Tech.
ChEBML_63995
Ki
6100±n/a nM
Citation
 Finke, PE; Shah, SK; Ashe, BM; Ball, RG; Blacklock, TJ; Bonney, RJ; Brause, KA; Chandler, GO; Cotton, M; Davies, P Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol. J Med Chem 35:3731-44 (1992) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50003160
Synonyms:
CHEMBL435611 | [(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl)-benzyl-amino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C20H22N2O9S
Mol. Mass.:
466.462
SMILES:
CO[C@@H]1[C@@H]2N(C1=O)C(C(=O)N(CC(O)=O)Cc1ccccc1)=C(COC(C)=O)CS2(=O)=O |t:23|
Structure:
Search PDB for entries with ligand similarity: