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Target
Carbonic anhydrase 2
Ligand
BDBM50003242
Substrate
n/a
Meas. Tech.
ChEMBL_45064 (CHEMBL659847)
Ki
15±n/a nM
Citation
 Hartman, GD; Halczenko, W; Smith, RL; Sugrue, MF; Mallorga, PJ; Michelson, SR; Randall, WC; Schwam, H; Sondey, JM 4-substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors. J Med Chem 35:3822-31 (1992) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50003242
Synonyms:
4-[3-(Isobutylamino-methyl)-benzoyl]-thiophene-2-sulfonic acid amide; hydrochloride | CHEMBL555186
Type:
Small organic molecule
Emp. Form.:
C16H20N2O3S2
Mol. Mass.:
352.472
SMILES:
CC(C)CNCc1cccc(c1)C(=O)c1csc(c1)S(N)(=O)=O
Structure:
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