Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50002332
Substrate
n/a
Meas. Tech.
ChEBML_176509
IC50
>1000±n/a nM
Citation
 Yevich, JP; New, JS; Lobeck, WG; Dextraze, P; Bernstein, E; Taylor, DP; Yocca, FD; Eison, MS; Temple, DL Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J Med Chem 35:4516-25 (1993) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50002332
Synonyms:
2-{4-[3,4-Bis-(4-fluoro-phenyl)-but-3-enyl]-piperazin-1-yl}-5-fluoro-pyrimidine | CHEMBL344577
Type:
Small organic molecule
Emp. Form.:
C24H23F3N4
Mol. Mass.:
424.4614
SMILES:
Fc1ccc(\C=C(/CCN2CCN(CC2)c2ncc(F)cn2)c2ccc(F)cc2)cc1
Structure:
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