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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50004157
Substrate
n/a
Meas. Tech.
ChEBML_217980
Ki
850±n/a nM
Citation
 Atwal, KS; Ahmed, SZ; Bird, JE; Delaney, CL; Dickinson, KE; Ferrara, FN; Hedberg, A; Miller, AV; Moreland, S; O'Reilly, BC Dihydropyrimidine angiotensin II receptor antagonists. J Med Chem 35:4751-63 (1993) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50004157
Synonyms:
2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-6-methyl-4-phenyl-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester | CHEMBL145017
Type:
Small organic molecule
Emp. Form.:
C32H34N2O4
Mol. Mass.:
510.6234
SMILES:
CCCCC1=NC(=C(C(C)N1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(=O)OCC)c1ccccc1 |c:6,t:4|
Structure:
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