Reaction Details Report a problem with these data
Target
Folylpolyglutamate synthase, mitochondrial
Ligand
BDBM50002471
Substrate
n/a
Meas. Tech.
ChEBML_68543
Ki
30±n/a nM
Citation
 Rosowsky, A; Forsch, RA; Reich, VE; Freisheim, JH; Moran, RG Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. J Med Chem 35:1578-88 (1992) [PubMed]  Article 
Target
Name:
Folylpolyglutamate synthase, mitochondrial
Synonyms:
FOLC_MOUSE | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Fpgs | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase
Type:
PROTEIN
Mol. Mass.:
64969.76
Organism:
Mus musculus
Description:
ChEMBL_68680
Residue:
587
Sequence:
MSWARSRLCSTLSLAAVSARGATTEGAARRGMSAWPAPQEPGMEYQDAVRTLNTLQTNASYLEQVKRQRSDPQAQLEAMEMYLARSGLQVEDLNRLNIIHVTGTKGKGSTCAFTERILRNYGLKTGFFSSPHMVQVRERIRINGKPISPELFTKHFWCLYNQLEEFKDDSHVSMPSYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKPGVPAFTVVQPEGPLAVLRDRAQQIGCPLYLCPPLEALEEVGLPLSLGLEGAHQRSNAALALQLAHCWLERQDHQDIQELKVSRPSIRWQLPLAPVFRPTPHMRRGLRDTVWPGRTQILQRGPLTWYLDGAHTTSSVQACVHWYRQSLERSKRTDGGSEVHILLFNSTGDRDSAALLKLLQPCQFDYAVFCPNVTEVSSIGNADQQNFTVTLDQVLLRCLQHQQHWNGLAEKQASSNLWSSCGPDPAGPGSLLLAPHPPQPTRTSSLVFSCISHALLWISQGRDPIFQPQSLPRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGVLKLLDPSMSQ
  
Inhibitor
Name:
BDBM50002471
Synonyms:
5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,4a,5,6,7,8-octahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | 5-Amino-2-{4-[(2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | CHEMBL289923
Type:
Small organic molecule
Emp. Form.:
C20H27N7O4
Mol. Mass.:
429.4729
SMILES:
NCCCC(NC(=O)c1ccc(NCC2CNc3nc(N)[nH]c(=O)c3C2)cc1)C(O)=O
Structure:
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