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Reaction Details
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TargetLeukocyte elastase
LigandBDBM50005901
Substrate/Competitorn/a
Meas. Tech.ChEMBL_96627
IC50 11000±n/a nM
Citation Zembower, DEKam, CMPowers, JCZalkow, LH Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. J Med Chem35:1597-605 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50005901
NameBDBM50005901
Synonyms:1-Hydroxy-2-methyl-anthraquinone | 1-hydroxy-2-methyl-9,10-anthraquinone | 1-hydroxy-2-methylanthracene-9,10-dione | CHEMBL42302
TypeSmall organic molecule
Emp. Form.C15H10O3
Mol. Mass.238.2381
SMILESCc1ccc2C(=O)c3ccccc3C(=O)c2c1O
Structure
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