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Target
Purine nucleoside phosphorylase
Ligand
BDBM50005795
Substrate
n/a
Meas. Tech.
ChEMBL_162185 (CHEMBL766705)
Ki
67±n/a nM
Citation
 Sircar, JC; Kostlan, CR; Gilbertsen, RB; Bennett, MK; Dong, MK; Cetenko, WJ Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-o J Med Chem 35:1605-9 (1992) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50005795
Synonyms:
2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one | CHEMBL285627 | PD-119229-2
Type:
Small organic molecule
Emp. Form.:
C10H10N6OS
Mol. Mass.:
262.291
SMILES:
Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1
Structure:
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