Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50005948
Substrate
n/a
Meas. Tech.
ChEBML_28339
IC50
2300±n/a nM
Citation
 Roth, BD; Blankley, CJ; Hoefle, ML; Holmes, A; Roark, WH; Trivedi, BK; Essenburg, AD; Kieft, KA; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem 35:1609-17 (1992) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50005948
Synonyms:
CHEMBL42575 | [2-(2,2-Dimethyl-dodecanoylamino)-3,5-dimethoxy-phenoxy]-acetic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C25H41NO6
Mol. Mass.:
451.5961
SMILES:
CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OCC(=O)OC
Structure:
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