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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50034348
Substrate
n/a
Meas. Tech.
ChEBML_581
Ki
0.300000±n/a nM
Citation
 Chidester, CG; Lin, CH; Lahti, RA; Haadsma-Svensson, SR; Smith, MW Comparison of 5-HT1A and dopamine D2 pharmacophores. X-ray structures and affinities of conformationally constrained ligands. J Med Chem 36:1301-15 (1993) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50034348
Synonyms:
(2aR,8bR)-2-Allyl-1,2,2a,3,4,8b-hexahydro-naphtho[2,1-b]azet-8-ol | (2aR,8bR)-2-allyl-1,2,2a,3,4,8b-hexahydronaphtho[2,1-b]azet-8-ol | (Recemic)2-Allyl-1,2,2a,3,4,8b-hexahydro-naphtho[2,1-b]azet-8-ol | CHEMBL285774
Type:
Small organic molecule
Emp. Form.:
C14H17NO
Mol. Mass.:
215.2909
SMILES:
Oc1cccc2CC[C@@H]3[C@@H](CN3CC=C)c12
Structure:
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