Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAGTR1
LigandBDBM82258
Substrate/Competitorn/a
Meas. Tech.ChEMBL_36155
Ki 15±n/a nM
Citation Winn, MDe, BZydowsky, TMAltenbach, RJBasha, FZBoyd, SABrune, MEBuckner, SACrowell, DDrizin, I 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. J Med Chem36:2676-88 (1993) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
AGTR1
Name:Angiotensin II receptor (AT-1) type-1
Synonyms:ANGIOTENSIN AT1 | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | Type-1A angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40910.53
Organism:RAT
Description:ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM82258
NameBDBM82258
Synonyms:CAS_114798-26-4 | Losartan | NSC_3961
TypeSmall organic molecule
Emp. Form.C22H23ClN6O
Mol. Mass.422.911
SMILESCCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a