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Target
Inositol polyphosphate-5-phosphatase A
Ligand
BDBM50046075
Substrate
n/a
Meas. Tech.
ChEMBL_4316 (CHEMBL618424)
Ki
16500±n/a nM
Citation
 Kozikowski, AP; Ognyanov, VI; Chen, C; Fauq, AH; Safrany, ST; Wilcox, RA; Nahorski, SR Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor. J Med Chem 36:3035-8 (1993) [PubMed]  Article 
Target
Name:
Inositol polyphosphate-5-phosphatase A
Synonyms:
5PTASE | I5P1_HUMAN | INPP5A | Type I inositol-1,4,5-trisphosphate 5-phosphatase
Type:
PROTEIN
Mol. Mass.:
47823.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_4316
Residue:
412
Sequence:
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
  
Inhibitor
Name:
BDBM50046075
Synonyms:
1D-2,3,6--trioxy- 1D-myo-Inositol 1,4,5-trisphosphate
Type:
Small organic molecule
Emp. Form.:
C6H9O13P3
Mol. Mass.:
382.0524
SMILES:
O[C@@H]1C(CCC(OP([O-])([O-])=O)[C@@H]1OP([O-])([O-])=O)OP([O-])([O-])=O
Structure:
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