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Target
Beta-2 adrenergic receptor
Ligand
BDBM50010891
Substrate
n/a
Meas. Tech.
ChEBML_37824
Ki
49900±n/a nM
Citation
 Macchia, B; Balsamo, A; Breschi, MC; Chiellini, G; Lapucci, A; Macchia, M; Manera, C; Martinelli, A; Martini, C; Scatizzi, R Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives. J Med Chem 36:3077-86 (1993) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2_BOVIN | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor | adrenergic Beta
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47141.18
Organism:
BOVINE
Description:
adrenergic Beta ADRB2 BOVINE::Q28044
Residue:
418
Sequence:
MGQPGNRSVFLLAPNASHAPDQNVTLERDEAWVVGMGILMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGACHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYLAITSPFKYQCLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRASHKEAINCYAKETCCDFFTNQPYAIASSIVSFYLPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNVSQVEQDGRSGLGQRRTSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIKDNLIRKEIYILLNWLGYINSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGCSSNSNDRTDYTGEQSGYHLGEEKDSELLCEDPPGTENFVNQQGTVPSDSIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50010891
Synonyms:
1-Aminomethyl-isochroman-5,6-diol | 1-Aminomethyl-isochroman-5,6-diol; hydrobromide | CHEMBL542683 | CHEMBL99361
Type:
Small organic molecule
Emp. Form.:
C10H13NO3
Mol. Mass.:
195.2151
SMILES:
NCC1OCCc2c(O)c(O)ccc12
Structure:
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