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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50042340
Substrate
n/a
Meas. Tech.
ChEBML_1317
Ki
360±n/a nM
Citation
 Sonesson, C; Boije, M; Svensson, K; Ekman, A; Carlsson, A; Romero, AG; Martin, IJ; Duncan, JN; King, LJ; Wikström, H Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. J Med Chem 36:3409-16 (1993) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50042340
Synonyms:
CHEMBL114433 | Trifluoro-methanesulfonic acid 7-dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-yl ester
Type:
Small organic molecule
Emp. Form.:
C17H24F3NO3S
Mol. Mass.:
379.438
SMILES:
CCCN(CCC)C1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1
Structure:
Search PDB for entries with ligand similarity: