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Target
Beta-2 adrenergic receptor
Ligand
BDBM50019061
Substrate
n/a
Meas. Tech.
ChEBML_30208
Ki
29000±n/a nM
Citation
 Chen, GT; King, M; Gusovsky, F; Creveling, CR; Daly, JW; Chen, BH; Nie, JY; Kirk, KL Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity. J Med Chem 36:3947-55 (1994) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_RAT | Adrb2 | Adrb2r | Adrenergic receptor beta
Type:
PROTEIN
Mol. Mass.:
46896.26
Organism:
Rattus norvegicus
Description:
ChEMBL_38603
Residue:
418
Sequence:
MEPHGNDSDFLLAPNGSRAPGHDITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKQAIDCYAKETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGRSGHGLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEQSAYQLGQEKENELLCEEAPGMEGFVNCQGTVPSLSIDSQGRNCNTNDSPL
  
Inhibitor
Name:
BDBM50019061
Synonyms:
(+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol | 4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol | 4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol(6-FNE) | CHEMBL281232
Type:
Small organic molecule
Emp. Form.:
C8H10FNO3
Mol. Mass.:
187.1683
SMILES:
NCC(O)c1cc(O)c(O)cc1F
Structure:
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