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Target
Multidrug transporter MdfA
Ligand
BDBM50046507
Substrate
n/a
Meas. Tech.
ChEMBL_68323 (CHEMBL680694)
IC50
1200±n/a nM
Citation
 Nelson, ML; Park, BH; Andrews, JS; Georgian, VA; Thomas, RC; Levy, SB Inhibition of the tetracycline efflux antiport protein by 13-thio-substituted 5-hydroxy-6-deoxytetracyclines. J Med Chem 36:370-7 (1993) [PubMed]  Article 
Target
Name:
Multidrug transporter MdfA
Synonyms:
Chloramphenicol resistance pump cmr | MDFA_ECOLI | Multidrug translocase mdfA | cmlA | cmr | mdfA
Type:
PROTEIN
Mol. Mass.:
44327.48
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_68323
Residue:
410
Sequence:
MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG
  
Inhibitor
Name:
BDBM50046507
Synonyms:
4-Dimethylamino-3,5,10,12,12a-pentahydroxy-6-(4-methoxy-phenylsulfanylmethyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide | CHEMBL339135
Type:
Small organic molecule
Emp. Form.:
C29H30N2O9S
Mol. Mass.:
582.622
SMILES:
COc1ccc(SC[C@@H]2C3[C@H](O)C4[C@H](N(C)C)C(=O)C(C(N)=O)C(=O)[C@@]4(O)C(=O)C3C(=O)c3c(O)cccc23)cc1
Structure:
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