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Target
Purine nucleoside phosphorylase
Ligand
BDBM50046864
Substrate
n/a
Meas. Tech.
ChEMBL_153326 (CHEMBL760478)
Ki
10000±n/a nM
Citation
 Chern, JW; Lee, HY; Chen, CS; Shewach, DS; Daddona, PE; Townsend, LB Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase. J Med Chem 36:1024-31 (1993) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50046864
Synonyms:
6-(2,8-Diamino-6-oxo-1,6-dihydro-purin-9-yl)-hexanoic acid | CHEMBL8246
Type:
Small organic molecule
Emp. Form.:
C11H16N6O3
Mol. Mass.:
280.2831
SMILES:
Nc1nc2c(nc(N)[nH]c2=O)n1CCCCCC(O)=O
Structure:
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