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Reaction Details
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TargetTubulin
LigandBDBM50044965
Substrate/Competitorn/a
Meas. Tech.ChEMBL_211332
IC50>40000±n/a nM
Citation Kuo, SCLee, HZJuang, JPLin, YTWu, TSChang, JJLednicer, DPaull, KDLin, CMHamel, E Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin. J Med Chem36:1146-56 (1993) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tubulin
Name:Tubulin
Synonyms:Tubulin beta chain
Type:PROTEIN
Mol. Mass.:49932.38
Organism:Bos taurus
Description:ChEMBL_211651
Residue:445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50044965
NameBDBM50044965
Synonyms:1-Methyl-2-phenyl-1H-quinolin-4-one | CHEMBL277048
TypeSmall organic molecule
Emp. Form.C16H13NO
Mol. Mass.235.2805
SMILESCn1c(cc(=O)c2ccccc12)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a