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Target
Translocator protein
Ligand
BDBM50041485
Substrate
n/a
Meas. Tech.
ChEMBL_37232 (CHEMBL651688)
IC50
560±n/a nM
Citation
 Fiorini, I; Nacci, V; Ciani, SM; Garofalo, A; Campiani, G; Savini, L; Novellino, E; Greco, G; Bernasconi, P; Mennini, T Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies. J Med Chem 37:1427-38 (1994) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50041485
Synonyms:
Acetic acid 9-chloro-5-phenyl-6-thia-10b-aza-benzo[e]azulen-4-yl ester | CHEMBL33042
Type:
Small organic molecule
Emp. Form.:
C20H14ClNO2S
Mol. Mass.:
367.849
SMILES:
CC(=O)OC1=C(Sc2ccc(Cl)cc2-n2cccc12)c1ccccc1 |t:4|
Structure:
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