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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50041734
Substrate
n/a
Meas. Tech.
ChEMBL_28198 (CHEMBL637691)
IC50
33±n/a nM
Citation
 Trivedi, BK; Purchase, TS; Holmes, A; Augelli-Szafran, CE; Essenburg, AD; Hamelehle, KL; Stanfield, RL; Bousley, RF; Krause, BR Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity. J Med Chem 37:1652-9 (1994) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50041734
Synonyms:
Acetic acid 2-[(2-acetoxy-ethyl)-(3-{1-[3-(2,6-diisopropyl-phenyl)-ureidomethyl]-cyclopentyl}-benzyl)-amino]-ethyl ester | CHEMBL294984
Type:
Small organic molecule
Emp. Form.:
C34H49N3O5
Mol. Mass.:
579.77
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(CCCC1)c1cccc(CN(CCOC(C)=O)CCOC(C)=O)c1
Structure:
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