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Target
Alpha-2A adrenergic receptor
Ligand
BDBM50036868
Substrate
n/a
Meas. Tech.
ChEMBL_33026 (CHEMBL643951)
IC50
40000±n/a nM
Citation
 Podona, T; Guardiola-Lemaître, B; Caignard, DH; Adam, G; Pfeiffer, B; Renard, P; Guillaumet, G 3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies. J Med Chem 37:1779-93 (1994) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADA2A_BOVIN | ADRA2A | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha-2Da adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha2A | adrenergic Alpha2D
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49275.13
Organism:
BOVINE
Description:
adrenergic Alpha2 0 BOVINE::Q28838
Residue:
452
Sequence:
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSGQPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATAAELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSSEHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50036868
Synonyms:
2-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl}-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one; compound with oxalic acid | CHEMBL51561
Type:
Small organic molecule
Emp. Form.:
C24H30N2O5S
Mol. Mass.:
458.57
SMILES:
CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1
Structure:
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