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Target
Neprilysin
Ligand
BDBM50038621
Substrate
n/a
Meas. Tech.
ChEMBL_144465 (CHEMBL755112)
IC50
190±n/a nM
Citation
 Gomez-Monterrey, I; Beaumont, A; Nemecek, P; Roques, BP; Fournie-Zaluski, MC New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition. J Med Chem 37:1865-73 (1994) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11
Type:
Enzyme
Mol. Mass.:
85570.75
Organism:
Oryctolagus cuniculus (rabbit)
Description:
NEP was purified to homogeneity from rabbit kidney.
Residue:
750
Sequence:
MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGTSWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILTKYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAAIVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
  
Inhibitor
Name:
BDBM50038621
Synonyms:
2-(2-Benzyl-4-mercapto-5-phenyl-pentanoylamino)-propionic acid | CHEMBL293794
Type:
Small organic molecule
Emp. Form.:
C21H25NO3S
Mol. Mass.:
371.493
SMILES:
CC(NC(=O)C(CC(S)Cc1ccccc1)Cc1ccccc1)C(O)=O
Structure:
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