Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50040524
Substrate
n/a
Meas. Tech.
ChEMBL_47953 (CHEMBL656242)
IC50
69200±n/a nM
Citation
 Holladay, MW; Kopecka, H; Miller, TR; Bednarz, L; Nikkel, AL; Bianchi, BR; Witte, DG; Shiosaki, K; Lin, CW; Asin, KE Tetrapeptide CCK-A agonists: effect of backbone N-methylations on in vitro and in vivo CCK activity. J Med Chem 37:630-5 (1994) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50040524
Synonyms:
(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-{[(S)-2-[(S)-3-(1H-indol-3-yl)-2-methylamino-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-succinamic acid | CHEMBL434674
Type:
Small organic molecule
Emp. Form.:
C40H50N8O7
Mol. Mass.:
754.8744
SMILES:
CN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N(C)[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
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