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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50035145
Substrate
n/a
Meas. Tech.
ChEMBL_202042 (CHEMBL809515)
IC50
0.40±n/a nM
Citation
 Moltzen, EK; Perregaard, J; Meier, E Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines. J Med Chem 38:2009-17 (1995) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50035145
Synonyms:
1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1,4'-piperidine] | CHEMBL59809
Type:
Small organic molecule
Emp. Form.:
C21H31NO2
Mol. Mass.:
329.4763
SMILES:
C(COC1CCCCC1)CN1CCC2(CC1)OCc1ccccc21
Structure:
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