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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50029301
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63038
Ki 17±n/a nM
Citation Reitz, ABBaxter, EWBennett, DJCodd, EEJordan, ADMalloy, EAMaryanoff, BEMcDonnell, MEOrtegon, MERenzi, MJ N-aryl-N'-benzylpiperazines as potential antipsychotic agents. J Med Chem38:4211-22 (1995) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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  Blast E-value cutoff:
BDBM50029301
NameBDBM50029301
Synonyms:1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-benzyl}-4-methyl-piperidine-2,6-dione with succinic acid
TypeSmall organic molecule
Emp. Form.C27H35N3O3
Mol. Mass.449.5851
SMILESCC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3C(=O)CC(C)CC3=O)c2)CC1
Structure
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