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Target
Dihydrofolate reductase
Ligand
BDBM50049156
Substrate
n/a
Meas. Tech.
ChEMBL_54113 (CHEMBL668271)
IC50
0.84±n/a nM
Citation
 Hart, BP; Haile, WH; Licato, NJ; Bolanowska, WE; McGuire, JJ; Coward, JK Synthesis and biological activity of folic acid and methotrexate analogues containing L-threo-(2S,4S)-4-fluoroglutamic acid and DL-3,3-difluoroglutamic acid. J Med Chem 39:56-65 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50049156
Synonyms:
(2R,4R)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-fluoro-pentanedioic acid | CHEMBL349572
Type:
Small organic molecule
Emp. Form.:
C20H21FN8O5
Mol. Mass.:
472.4297
SMILES:
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@H](C[C@@H](F)C(O)=O)C(O)=O
Structure:
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