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Target
Cardiac ryanodine receptor 2
Ligand
BDBM50044994
Substrate
n/a
Meas. Tech.
ChEMBL_196057 (CHEMBL803056)
Ki
1.8±n/a nM
Citation
 Jefferies, PR; Gengo, PJ; Watson, MJ; Casida, JE Ryanodine action at calcium release channels. 2. relation to substituents of the cyclohexane ring. J Med Chem 39:2339-46 (1996) [PubMed]  Article 
Target
Name:
Cardiac ryanodine receptor 2
Synonyms:
Ryanodine receptor 2
Type:
PROTEIN
Mol. Mass.:
19475.06
Organism:
Canis familiaris
Description:
ChEMBL_196057
Residue:
172
Sequence:
ALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSE
  
Inhibitor
Name:
BDBM50044994
Synonyms:
2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-trimethyl-(2R,3S,7S,12R)-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadec-12-yl 1H-2-pyrrolecarboxylate(Ryanodine) | Ryanodine
Type:
Small organic molecule
Emp. Form.:
C25H35NO9
Mol. Mass.:
493.5467
SMILES:
CC(C)[C@@]1(O)[C@@H](OC(=O)c2cc[nH]c2)[C@@]2(O)[C@]3(C)C[C@@]4(O)O[C@@]5([C@H](O)[C@@H](C)CC[C@]35O)[C@@]2(O)[C@]14C |r,TLB:28:29:31.33:21,34:33:21:29.16.18,THB:14:16:31.33:21,14:31:21:29.16.18,3:33:21:29.16.18,33:19:29:31.14,32:31:21:29.16.18|
Structure:
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