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Target
Translocator protein
Ligand
BDBM50038254
Substrate
n/a
Meas. Tech.
ChEMBL_37061 (CHEMBL652449)
Ki
44±n/a nM
Citation
 Campiani, G; Nacci, V; Fiorini, I; De Filippis, MP; Garofalo, A; Ciani, SM; Greco, G; Novellino, E; Williams, DC; Zisterer, DM; Woods, MJ; Mihai, C; Manzoni, C; Mennini, T Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific"peripheral-type" benzodiazepine receptor ligands. J Med Chem 39:3435-50 (1996) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50038254
Synonyms:
Acetic acid 8-methyl-5-phenyl-6-thia-10b-aza-benzo[e]azulen-4-yl ester | CHEMBL324500
Type:
Small organic molecule
Emp. Form.:
C21H17NO2S
Mol. Mass.:
347.43
SMILES:
CC(=O)OC1=C(Sc2cc(C)ccc2-n2cccc12)c1ccccc1 |t:4|
Structure:
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