Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50053539
Substrate
n/a
Meas. Tech.
ChEMBL_3826 (CHEMBL618012)
IC50
70±n/a nM
Citation
 Delorme, DDucharme, YBrideau, CChan, CCChauret, NDesmarais, SDubé, DFalgueyret, JPFortin, RGuay, JHamel, PJones, TRLépine, CLi, CMcAuliffe, MMcFarlane, CSNicoll-Griffith, DARiendeau, DYergey, JAGirard, Y Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability. J Med Chem 39:3951-70 (1996) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | 5-lipoxygenase/FLAP | ALOX5 | Arachidonate 5-lipoxygenase | LOG5 | LOX5_HUMAN
Type:
Enzyme
Mol. Mass.:
77972.74
Organism:
Homo sapiens (Human)
Description:
Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay.
Residue:
674
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50053539
Synonyms:
4-{3-[7-(4,5-Dihydro-oxazol-2-yl)-5-furan-3-yl-naphthalen-2-yloxymethyl]-phenyl}-tetrahydro-pyran-4-ol | CHEMBL129056
Type:
Small organic molecule
Emp. Form.:
C29H27NO5
Mol. Mass.:
469.5284
SMILES:
OC1(CCOCC1)c1cccc(COc2ccc3c(cc(cc3c2)C2=NCCO2)-c2ccoc2)c1 |t:27|
Structure:
Search PDB for entries with ligand similarity: