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TargetDihydroorotate dehydrogenase
LigandBDBM50054552
Substrate/Competitorn/a
Meas. Tech.ChEMBL_52873
IC50 445±n/a nM
Citation Kuo, EAHambleton, PTKay, DPEvans, PLMatharu, SSLittle, EMcDowall, NJones, CBHedgecock, CJYea, CMChan, AWHairsine, PWAger, IRTully, WRWilliamson, RAWestwood, R Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds. J Med Chem39:4608-21 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase
Name:Dihydroorotate dehydrogenase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:42711.08
Organism:Mus musculus
Description:ChEMBL_1366444
Residue:395
Sequence:
MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVR
VISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGIN
LGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQER
DALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTF
LGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50054552
NameBDBM50054552
Synonyms:(Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methylsulfanyl-phenyl)-acrylamide | CHEMBL143816
TypeSmall organic molecule
Emp. Form.C14H14N2O2S
Mol. Mass.274.338
SMILESCSc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1
Structure
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n/a