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TargetNeuronal acetylcholine receptor
LigandBDBM50454437
Substrate/Competitorn/a
Meas. Tech.ChEMBL_144168
IC50 19000±n/a nM
Citation Hardick, DJBlagbrough, ISCooper, GPotter, BVCritchley, TWonnacott, S Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding. J Med Chem39:4860-6 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor
Name:Neuronal acetylcholine receptor
Synonyms:Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:Enzyme
Mol. Mass.:56502.44
Organism:Rattus norvegicus (Rat)
Description:Q05941
Residue:502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50454437
NameBDBM50454437
Synonyms:DELSOLINE | Delsoline
TypeSmall organic molecule
Emp. Form.C25H41NO7
Mol. Mass.467.5955
SMILES[H][C@]12CC3[C@]([H])([C@H]1OC)[C@](O)(C[C@@H]2OC)[C@@]1(O)[C@@H](OC)[C@@]2([H])[C@@]33[C@@H](O)CC[C@@]2(COC)CN(CC)[C@@]13[H] |TLB:15:35:20:23.26.25,9:15:22:27.32.31,28:27:22:15.17,3:22:15.17:27.32.31,THB:26:27:22:15.17,23:22:15.17:27.32.31,18:17:22:27.32.31,7:6:3.2:9.11.12,33:32:22:15.17,33:32:20:23.26.25,6:4:35:20.17,24:23:20:35.32.31,11:9:35:20.17,2:3:35:20.17|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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