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Target
Proteinase-activated receptor 1
Ligand
BDBM50054857
Substrate
n/a
Meas. Tech.
ChEMBL_209251 (CHEMBL815692)
IC50
99±n/a nM
Citation
 Bernatowicz, MS; Klimas, CE; Hartl, KS; Peluso, M; Allegretto, NJ; Seiler, SM Development of potent thrombin receptor antagonist peptides. J Med Chem 39:4879-87 (1997) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50054857
Synonyms:
2-[2-[2-{Acetyl-[(E)-3-(4-chloro-phenyl)-acryloyl]-amino}-3-(4-fluoro-phenyl)-propionylamino]-3-(4-guanidino-phenyl)-propionylamino]-4-methyl-pentanoic acid (1-carbamoyl-4-guanidino-butyl)-amide | CHEMBL344767
Type:
Small organic molecule
Emp. Form.:
C42H53ClFN11O6
Mol. Mass.:
862.392
SMILES:
[#6]-[#6](-[#6])-[#6]-[#6](-[#7]-[#6](=O)-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c1ccc(F)cc1)-[#7](-[#6](-[#6])=O)-[#6](=O)-[#6]=[#6]-c1ccc(Cl)cc1)-[#6](=O)-[#7]-[#6](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7])-[#6](-[#7])=O |w:39.41|
Structure:
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