Reaction Details
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Proteinase-activated receptor 1
Ligand
BDBM50054884
Substrate
n/a
Meas. Tech.
ChEMBL_209251 (CHEMBL815692)
IC50
1180±n/a nM
Citation
Bernatowicz, MS; Klimas, CE; Hartl, KS; Peluso, M; Allegretto, NJ; Seiler, SM Development of potent thrombin receptor antagonist peptides. J Med Chem 39:4879-87 (1997) [PubMed] Article More Info.:
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
Inhibitor
Name:
BDBM50054884
Synonyms:
2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3-(4-fluoro-phenyl)-propionylamino]-3-(4-methoxy-phenyl)-propionylamino]-4-methyl-pentanoic acid (1-carbamoyl-4-guanidino-butyl)-amide | CHEMBL344728
Type:
Small organic molecule
Emp. Form.:
C42H53FN8O7
Mol. Mass.:
800.918
SMILES:
COc1ccc(CC(NC(=O)C(Cc2ccc(F)cc2)N(C(C)=O)C(=O)C=Cc2ccccc2)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)cc1 |w:27.28|
Structure:
