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Target
Metabotropic glutamate receptor 3
Ligand
BDBM50060719
Substrate
n/a
Meas. Tech.
ChEMBL_106390 (CHEMBL717245)
EC50
>1000000±n/a nM
Citation
 Ahmadian, H; Nielsen, B; Bräuner-Osborne, H; Johansen, TN; Stensbøl, TB; Sløk, FA; Sekiyama, N; Nakanishi, S; Krogsgaard-Larsen, P; Madsen, U (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors. J Med Chem 40:3700-5 (1997) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 3
Synonyms:
GRM3_RAT | Gprc1c | Grm3 | Mglur3 | glutamate receptor, metabotropic 3 precursor
Type:
Protein
Mol. Mass.:
98971.84
Organism:
Rattus norvegicus (Rat)
Description:
P31422
Residue:
879
Sequence:
MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
  
Inhibitor
Name:
BDBM50060719
Synonyms:
(S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid | 2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid | 2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid(S-homo-AMPA) | CHEMBL315268
Type:
Small organic molecule
Emp. Form.:
C8H12N2O4
Mol. Mass.:
200.1919
SMILES:
Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: