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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50369339
Substrate
n/a
Meas. Tech.
ChEMBL_202894 (CHEMBL810011)
IC50
55±n/a nM
Citation
 Kenny, B; Ballard, S; Blagg, J; Fox, D Pharmacological options in the treatment of benign prostatic hyperplasia. J Med Chem 40:1293-315 (1997) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50369339
Synonyms:
TUROSTERIDE
Type:
Small organic molecule
Emp. Form.:
C27H45N3O3
Mol. Mass.:
459.6645
SMILES:
CC(C)NC(=O)N(C(C)C)C(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Structure:
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