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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50057483
Substrate
n/a
Meas. Tech.
ChEMBL_205217 (CHEMBL816491)
IC50
8±n/a nM
Citation
 Kenny, B; Ballard, S; Blagg, J; Fox, D Pharmacological options in the treatment of benign prostatic hyperplasia. J Med Chem 40:1293-315 (1997) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50057483
Synonyms:
4-(3-{4-[1-(4-Propyl-phenoxy)-ethyl]-benzoyl}-indol-1-yl)-butyric acid | CHEMBL279745
Type:
Small organic molecule
Emp. Form.:
C30H31NO4
Mol. Mass.:
469.5714
SMILES:
CCCc1ccc(OC(C)c2ccc(cc2)C(=O)c2cn(CCCC(O)=O)c3ccccc23)cc1
Structure:
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