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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM48918
Substrate
n/a
Meas. Tech.
ChEMBL_139635 (CHEMBL748248)
IC50
5200±n/a nM
Citation
 Pei, XF; Gupta, TH; Badio, B; Padgett, WL; Daly, JW 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. J Med Chem 41:2047-55 (1998) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM48918
Synonyms:
2-acetoxypropyl(trimethyl)ammonium;chloride | 2-acetyloxypropyl(trimethyl)ammonium;chloride | 2-acetyloxypropyl(trimethyl)azanium;chloride | METHACHOLINE | METHACHOLINE CHLORIDE | MLS000069656 | SMR000059224 | cid_6114
Type:
Small organic molecule
Emp. Form.:
C8H18NO2
Mol. Mass.:
160.2335
SMILES:
CC(C[N+](C)(C)C)OC(C)=O
Structure:
Search PDB for entries with ligand similarity: