Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM50041144
Substrate
n/a
Meas. Tech.
ChEMBL_146910 (CHEMBL757498)
Ki
0.830000±n/a nM
Citation
 Tourwé, D; Mannekens, E; Diem, TN; Verheyden, P; Jaspers, H; Tóth, G; Péter, A; Kertész, I; Török, G; Chung, NN; Schiller, PW Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile. J Med Chem 41:5167-76 (1999) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50041144
Synonyms:
(S)-2-Amino-N-((5S,8S)-5-benzyl-4,7,13,16-tetraoxo-hexadecahydro-3a,6,12,15-tetraaza-cyclopentacyclopentadecen-8-yl)-3-(4-hydroxy-phenyl)-propionamide | CHEMBL557035
Type:
Small organic molecule
Emp. Form.:
C37H39N5O5
Mol. Mass.:
633.7361
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: