Reaction Details Report a problem with these data
Target
3',5'-cyclic-AMP phosphodiesterase
Ligand
BDBM14361
Substrate
n/a
Meas. Tech.
ChEMBL_155663 (CHEMBL763047)
IC50
3630±n/a nM
Citation
 Watanabe, N; Adachi, H; Takase, Y; Ozaki, H; Matsukura, M; Miyazaki, K; Ishibashi, K; Ishihara, H; Kodama, K; Nishino, M; Kakiki, M; Kabasawa, Y 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. J Med Chem 43:2523-9 (2000) [PubMed]  Article 
Target
Name:
3',5'-cyclic-AMP phosphodiesterase
Synonyms:
Phosphodiesterase 4A
Type:
PROTEIN
Mol. Mass.:
13615.65
Organism:
Sus scrofa
Description:
ChEMBL_155848
Residue:
118
Sequence:
PWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVDIPSPTMKDHEKQQAPRQRPSQQPPPPGPQFQPMSQITGVKKLMHSSSLNEDSSIPRFGVKTDQEELLAQEL
  
Inhibitor
Name:
BDBM14361
Synonyms:
(R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one | 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one | Adeo | CHEMBL63 | Rolipram
Type:
Small organic molecule
Emp. Form.:
C16H21NO3
Mol. Mass.:
275.3428
SMILES:
COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Structure:
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