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TargetGRM8
LigandBDBM86717
Substrate/Competitorn/a
Meas. Tech.ChEMBL_104492
Ki>100000±n/a nM
Citation Bräuner-Osborne, HEgebjerg, JNielsen, EOMadsen, UKrogsgaard-Larsen, P Ligands for glutamate receptors: design and therapeutic prospects. J Med Chem43:2609-45 (2000) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
GRM8
Name:Metabotropic glutamate receptor 8
Synonyms:Metabotropic glutamate receptor 8 | mGluR8 | metabotropic glutamate 8
Type:Enzyme Catalytic Domain
Mol. Mass.:101759.58
Organism:Homo sapiens (Human)
Description:metabotropic glutamate 8 GRM8 HUMAN::O00222
Residue:908
Sequence:
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
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  Blast E-value cutoff:
BDBM86717
NameBDBM86717
Synonyms:CAS_5218788 | CHEMBL88553 | NSC_5218788 | SIB-1757
TypeSmall organic molecule
Emp. Form.C12H11N3O
Mol. Mass.213.2352
SMILESCc1ccc(O)c(N=Nc2ccccc2)n1 |w:7.6|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a