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Target
Leukotriene A-4 hydrolase
Ligand
BDBM50085277
Substrate
n/a
Meas. Tech.
ChEMBL_96941 (CHEMBL879999)
IC50
11±n/a nM
Citation
 Penning, TD; Chandrakumar, NS; Chen, BB; Chen, HY; Desai, BN; Djuric, SW; Docter, SH; Gasiecki, AF; Haack, RA; Miyashiro, JM; Russell, MA; Yu, SS; Corley, DG; Durley, RC; Kilpatrick, BF; Parnas, BL; Askonas, LJ; Gierse, JK; Harding, EI; Highkin, MK; Kachur, JF; Kim, SH; Krivi, GG; Villani-Price, D; Pyla, EY; Smith, WG Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. J Med Chem 43:721-35 (2000) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50085277
Synonyms:
1-{2-[4-(Difluoro-phenyl-methyl)-phenoxy]-ethyl}-pyrrolidine | CHEMBL349189
Type:
Small organic molecule
Emp. Form.:
C19H21F2NO
Mol. Mass.:
317.3729
SMILES:
FC(F)(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Structure:
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