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Target
Leukotriene A-4 hydrolase
Ligand
BDBM50085244
Substrate
n/a
Meas. Tech.
ChEMBL_220427 (CHEMBL841667)
IC50
510±n/a nM
Citation
 Penning, TD; Chandrakumar, NS; Chen, BB; Chen, HY; Desai, BN; Djuric, SW; Docter, SH; Gasiecki, AF; Haack, RA; Miyashiro, JM; Russell, MA; Yu, SS; Corley, DG; Durley, RC; Kilpatrick, BF; Parnas, BL; Askonas, LJ; Gierse, JK; Harding, EI; Highkin, MK; Kachur, JF; Kim, SH; Krivi, GG; Villani-Price, D; Pyla, EY; Smith, WG Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. J Med Chem 43:721-35 (2000) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50085244
Synonyms:
1-[3-(4-Benzyl-phenyl)-cyclobutyl]-pyrrolidine | CHEMBL351422
Type:
Small organic molecule
Emp. Form.:
C21H25N
Mol. Mass.:
291.4299
SMILES:
C(c1ccccc1)c1ccc(cc1)C1C[C@@H](C1)N1CCCC1 |wU:15.19,(5.75,-16.33,;4.44,-17.11,;3.09,-16.34,;1.78,-17.11,;1.78,-18.65,;3.09,-19.42,;4.44,-18.65,;7.1,-17.08,;7.1,-18.62,;8.44,-19.39,;9.76,-18.62,;9.75,-17.07,;8.42,-16.31,;11.1,-19.38,;11.52,-20.85,;12.99,-20.45,;12.59,-18.96,;14.34,-21.22,;15.54,-20.28,;16.82,-21.15,;16.37,-22.63,;14.83,-22.66,)|
Structure:
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