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Target
Protein kinase C alpha type
Ligand
BDBM50087241
Substrate
n/a
Meas. Tech.
ChEMBL_153127 (CHEMBL759066)
Ki
28.6±n/a nM
Citation
 Nacro, K; Sigano, DM; Yan, S; Nicklaus, MC; Pearce, LL; Lewin, NE; Garfield, SH; Blumberg, PM; Marquez, VE An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P). J Med Chem 44:1892-904 (2001) [PubMed]  Article 
Target
Name:
Protein kinase C alpha type
Synonyms:
KPCA_BOVIN | PKC-alpha | PRKCA | Protein Kinase C, alpha | Protein kinase C alpha
Type:
Enzyme
Mol. Mass.:
76842.76
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
672
Sequence:
MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRLSEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVELRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
  
Inhibitor
Name:
BDBM50087241
Synonyms:
3-Isopropyl-4-methyl-pentanoic acid (S)-1-hydroxymethyl-2-(3-isopropyl-4-methyl-pentanoyloxy)-ethyl ester | 3-Isopropyl-4-methyl-pentanoic acid 1-hydroxymethyl-2-(3-isopropyl-4-methyl-pentanoyloxy)-ethyl ester | 3-Isopropyl-4-methyl-pentanoic acid 3-hydroxy-2-(3-isopropyl-4-methyl-pentanoyloxy)-propyl ester | CHEMBL289230
Type:
Small organic molecule
Emp. Form.:
C21H40O5
Mol. Mass.:
372.5393
SMILES:
CC(C)C(CC(=O)OC[C@H](CO)OC(=O)CC(C(C)C)C(C)C)C(C)C
Structure:
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