Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50100699
Substrate
n/a
Meas. Tech.
ChEMBL_48588 (CHEMBL662468)
IC50
>10000±n/a nM
Citation
 Bartolomé-Nebreda, JM; Patiño-Molina, R; Martín-Martínez, M; Gómez-Monterrey, I; García-López, MT; González-Muñiz, R; Cenarruzabeitia, E; Latorre, M; Del Río, J; Herranz, R 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position. J Med Chem 44:2219-28 (2001) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin B receptor | Cholecystokinin receptor | GASR_RAT | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48980.43
Organism:
RAT
Description:
Cholecystokinin A CCKBR RAT::P30553
Residue:
452
Sequence:
MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50100699
Synonyms:
3-{5-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-1,3-dioxo-hexahydro-pyrido[1,2-c]pyrimidin-2-yl}-benzoic acid | CHEMBL265322
Type:
Small organic molecule
Emp. Form.:
C31H35N5O7
Mol. Mass.:
589.6389
SMILES:
CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1CCCN2C1CC(=O)N(C2=O)c1cccc(c1)C(O)=O
Structure:
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