Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50100703
Substrate
n/a
Meas. Tech.
ChEMBL_50180 (CHEMBL662395)
IC50
>1000±n/a nM
Citation
 Bartolomé-Nebreda, JM; Patiño-Molina, R; Martín-Martínez, M; Gómez-Monterrey, I; García-López, MT; González-Muñiz, R; Cenarruzabeitia, E; Latorre, M; Del Río, J; Herranz, R 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position. J Med Chem 44:2219-28 (2001) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49676.37
Organism:
RAT
Description:
Cholecystokinin central 0 RAT::P30551
Residue:
444
Sequence:
MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
  
Inhibitor
Name:
BDBM50100703
Synonyms:
2-{5-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-1,3-dioxo-hexahydro-pyrido[1,2-c]pyrimidin-2-yl}-3-phenyl-propionic acid methyl ester | CHEMBL70575
Type:
Small organic molecule
Emp. Form.:
C34H41N5O7
Mol. Mass.:
631.7186
SMILES:
COC(=O)C(Cc1ccccc1)N1C(=O)CC2C(CCCN2C1=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Structure:
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