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Target
Excitatory amino acid transporter 3
Ligand
BDBM50102486
Substrate
n/a
Meas. Tech.
ChEMBL_64114 (CHEMBL677659)
Ki
42000±n/a nM
Citation
 Campiani, G; De Angelis, M; Armaroli, S; Fattorusso, C; Catalanotti, B; Ramunno, A; Nacci, V; Novellino, E; Grewer, C; Ionescu, D; Rauen, T; Griffiths, R; Sinclair, C; Fumagalli, E; Mennini, T A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents. J Med Chem 44:2507-10 (2001) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_RAT | Eaac1 | Eaat3 | Slc1a1
Type:
PROTEIN
Mol. Mass.:
56770.16
Organism:
Rattus norvegicus
Description:
ChEMBL_64112
Residue:
523
Sequence:
MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGIVVGVLVRGHSELSNLDKFYFAFPGEILMRMLKLVILPLIISSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEYKIVGLYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRKNPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQVDVSSEVNIVNPFALEPTILDNEDSDTKKSYVNGGFSVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM50102486
Synonyms:
2-Phenyl-4,5-dihydro-oxazole-4,5-dicarboxylic acid | CHEMBL86279
Type:
Small organic molecule
Emp. Form.:
C11H9NO5
Mol. Mass.:
235.1929
SMILES:
OC(=O)[C@H]1OC(=N[C@@H]1C(O)=O)c1ccccc1 |c:5|
Structure:
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